Lowest Price
Or we match it + 5% discount
Credit
On late delivery
+ Credit
For extra customs duties
Lowest Price
Or we match it + 5% discount
Credit
On late delivery
+ Credit
For extra customs duties
Lowest Price
Guaranteed
+ Credit
for extra duties
Credit
for delay
Lowest Price
Or we match it + 5% discount
Credit
On late delivery
+ Credit
For extra customs duties
Lowest Price
Or we match it + 5% discount
Credit
On late delivery
+ Credit
For extra customs duties
Lowest Price
Guaranteed
+ Credit
for extra duties
Credit
for delay
Image 1 of Hardcover for the product Gene Targeting Protocols - Eric B. Kmiec
Gene Targeting Protocols - Eric B. Kmiec
Regular price 791.65 ILS
Regular price Sale price 879.64 ILS 791.65 ILS 10 percent off

Description

Gene Targeting Protocols - Eric B. Kmiec

About The Product:

The potential now exists in many experimental systems to transfer a cloned, modified gene back into the genome of the host organism. In the ideal situation, the cloned gene is returned to its homologous location in the genome and becomes inserted at the target locus. This process is a controlled means for the repair of DNA damage and ensures accurate chromosome disjunction during meiosis. The paradigm for thinking about the mechanism of this p- cess has emerged primarily from two sources: (1) The principles of reaction mechanics have come from detailed biochemical analyses of the RecA protein purified from Escherichia coli; and (2) the principles of information transfer have been derived from genetic studies carried out in bacteriophage and fungi. A compelling picture of the process of homologous pairing and DNA strand exchange has been influential in directing investigators interested in gene t- geting experiments. The ability to find and pair homologous DNA molecules enables ac- rate gene targeting and is the central phenomenon underlying genetic recombi- tion. Biochemically, the overall process can be thought of as a series of steps in a reaction pathway whereby DNA molecules are brought into homologous register, the four-stranded Holliday structure intermediate is formed, hete- duplex DNA is extended, and DNA strands are exchanged. Not much is known about the biochemical pathway leading to homologous recombination in euka- otes.

Product Details:

  • Author: Eric B. Kmiec
  • Language: English
  • No. of Pages: 248
  • Dimensions: 6.5 x 0.75 x 9.5 inches
  • Publisher: Humana Press
  • Publication Date: 2000
  • Legal Disclaimer : Product color may slightly vary due to photographic lighting sources or your monitor settings.

    Trustpilot
    from 4400+ reviews
    72419
    Verified Reviews
    Customers rate us 4.6/5 based on 75194 reviews.
    Google
    from 2500+ reviews
    Flat 12% Off on Dista App
    Flat 12% Off on Dista App Use Code: APPFIRST
    DOWNLOAD APP DOWNLOAD APP
    Get our app now!
    Scan the QR code below!
    QR code to download the app